Day 68 of 150 Memory Difficulty 8/10

Recalling a memory briefly makes it editable

Quick answer

Recalling a memory briefly makes it editable. Today's question (Memory reconsolidation) asks about a finding from Nader, K., Schafe, G. E., & LeDoux, J. E. in 2000. The correct option is Long after conditioning, immediately after the memory was reactivated by a reminder — full explanation, primary source, and glossary cross-links below.

Today's question

Nader, Schafe, and LeDoux (2000) showed that infusing anisomycin into the rat amygdala disrupted a fear memory only under one condition. What condition?

  1. A Immediately after initial fear conditioning
  2. B Long after conditioning, with no reminder cue
  3. C Long after conditioning, immediately after the memory was reactivated by a reminder
  4. D Before any conditioning had occurred
Reveal the answer and explanation

Correct: C — Long after conditioning, immediately after the memory was reactivated by a reminder

Nader, Schafe, and LeDoux (2000) demonstrated reconsolidation: a previously stable, long-stored fear memory became transiently labile when reactivated by a reminder cue, and a protein-synthesis inhibitor (anisomycin) infused into the lateral amygdala during this reactivation window erased the memory. Without reactivation, the same drug had no effect — old memories sat sealed. This finding overturned the classical view that consolidation happens once. Each act of remembering re-opens a brief synthesis-dependent window in which the trace can be modified, strengthened, or weakened — with implications for both PTSD treatment and theories of how we update beliefs.

About the source

Nader, K., Schafe, G. E., & LeDoux, J. E. (2000). Fear memories require protein synthesis in the amygdala for reconsolidation after retrieval. Nature, 406(6797), 722–726.

Every Cognition Bible question cites a primary source — a paper, book chapter, or monograph that exists, that we can point to on Google Scholar, and whose finding the question accurately summarizes. No fabricated authority strings, no name-drops without paper-level grounding.

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