Day 27 of 150 Memory Difficulty 9/10
Long-term potentiation strengthens synapses for hours to days
Quick answer
Long-term potentiation strengthens synapses for hours to days. Today's question (Long-term potentiation) asks about a finding from Bliss, T. V. P., & Lømo, T. in 1973. The correct option is Long-lasting strengthened synaptic transmission — full explanation, primary source, and glossary cross-links below.
Today's question
Bliss & Lømo's discovery of long-term potentiation (LTP) in 1973 showed that brief high-frequency stimulation of hippocampal synapses produces:
Reveal the answer and explanation
Correct: C — Long-lasting strengthened synaptic transmission
Working in anaesthetized rabbit hippocampus, Bliss & Lømo (1973) demonstrated that a brief tetanic stimulus produces a persistent enhancement of synaptic responses that lasts hours to days. LTP is the dominant cellular model for how memories are physically stored — Hebb's "fire together, wire together" given a mechanism. The discovery launched five decades of molecular memory research and remains central to translational work on Alzheimer's disease.
About the source
Bliss, T. V. P., & Lømo, T. (1973). Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path. Journal of Physiology, 232(2), 331–356.
Every Cognition Bible question cites a primary source — a paper, book chapter, or monograph that exists, that we can point to on Google Scholar, and whose finding the question accurately summarizes. No fabricated authority strings, no name-drops without paper-level grounding.
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